Figure 5.

Muscle strength assessment in ∼7-mo-old R58Q mutant male mice compared with ∼7-mo-old WT male mice. A) Grip strength expressed in newtons (N) (left) and grip strength in N/BW (body weight) in newtons per gram (right) for forelimbs (2p), 4 limbs (4p), and Δstrength (4p-2p), which is the difference in grip strength between 4 limbs and forelimbs for both genotypes. Each point represents 1 animal subjected to 4 independent measurements of force. B) Total time that the mice can spend hanging from a wire with their 4 paws before the first fall (left), and the ratio between the wire-hanging time and the animal body weight (right). Each point represents 1 measurement per animal in 3 consecutive trails. Data are the average ± sem; relevant significance values by Student’s t test are depicted.