. 2018 Oct 26;33(3):3152–3166. doi: 10.1096/fj.201801402R

TABLE 3.

Differentially expressed proteins in the hearts and SOL muscles of R58Q mice compared with WT RLC animals

Protein	Gene_Mouse	UniProt ID	MW kDa	FC R58Q vs. WT
Protein	Gene_Mouse	UniProt ID	MW kDa	Heart	SOL
Metabolic process/proteins related to enzyme activity/transport
Hemopexina^a	HEMO	Q91X72	51	1.40	1.37
Protein disulfide-isomerase A3^a	PDIA3	P27773	57	1.33	1.28
78 kDa glucose-regulated protein^a	GRP78	P20029	72	1.21	1.19
Hexokinase-1	HXK1	P17710	108	1.15
Hexokinase-2	E9Q5B5	E9Q5B5	99		−1.11
Serum albumin^a	ALBU	P07724	69	1.12	1.17
Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial^b	ACADV	P50544	71	−1.14	−1.12
Glycogen phosphorylase, muscle form^b	PYGM	Q9WUB3	97	−1.12	−1.1
Calcium-binding proteins
Calreticulin^a	CALR	P14211	48	1.41	1.24
Cluster of annexin A1^a	ANXA1	P10107	39	1.53
Cluster of annexin A2^a	ANXA2	P07356	39	1.33
Annexin A5^a	ANXA5	P48036	36	1.45
Annexin A6^a	ANXA6	P14824	76	1.11
Annexin A7^a	ANXA7	Q07076	50	1.22
Annexin^a	F8WIT2	F8WIT2	75		1.20
Calsequestrin-2^b	CASQ2	O09161	48	−1.12	−1.46
Ryanodine receptor 2^b	RYR2	E9Q401	565	−1.11
Ryanodine receptor 1^b	K3W4M2	K3W4M2	565		−1.12
Sarcomeric/contractile and cytoskeletal proteins
α-Actinin-4	ACTN4	P57780	105	1.23
α-Actinin-2	ACTN2	Q9JI91	104		−1.21
Desmin^a	DESM	P31001	53	1.46	1.13
Xin actin-binding repeat-containing protein 2^a	XIRP2	Q4U4S6	428	1.56
Xin actin-binding repeat-containing protein 1^a	E9QQ93	E9QQ93	124		1.17
Cysteine and glycine-rich protein 3^a	CSRP3	P50462	21	1.31	1.27
Prelamin-A/C^a	LMNA	P48678	74	1.39	1.31
Tropomyosin α-4 chain	TPM4	Q6IRU2	28	1.43
Tropomyosin α-3 chain	E9Q5J9	E9Q5J9	33		1.57
Tropomyosin β chain	TPM2	P58774	33		1.47
Filamin-B	FLNB	Q80X90	278	1.21
Filamin-C	D3YW87	Q80X90	287	1.21	−1.1
Cell growth/transcription/chaperones
Nucleolin^a	NUCL	P09405	77	1.21	1.33
Heterogeneous nuclear RNP A2/B1^a	ROA2	O88569	37	1.16	1.35
Protein AHNAK^a	E9Q616	E9Q616	604	1.21	1.27
Heterogeneous nuclear RNP L (fragment)^a	G5E924	G5E924	67	1.18	1.18
Galectin-1^a	LEG1	P16045	15	1.38	1.42

FC <1 indicate proteins that were significantly down-regulated in R58Q vs. WT muscles, whereas FC >1 indicate proteins that were significantly up-regulated in R58Q vs. WT muscles, with significance defined as P < 0.05. A Mann-Whitney U test was used to calculate the Bonferroni-corrected significance values (P < 0.00005 for SOL and P < 0.00002 for heart proteins). ^a,bProteins simultaneously up-regulated (a) and down-regulated (b) in the hearts and SOL muscles of R58Q vs.WT mice.