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. 2019 Feb 19;33(3):4225–4235. doi: 10.1096/fj.201801973R

Figure 8.

Figure 8

Structural stability analyses of 94-341p53β-dimer-, Δ133p53β-dimer-, and Δ160p53β-dimer-DNA complex suggest that Δ133p53β-dimer could form stable complex with p53 response element. A) The time evolution of Cα RMSD of p53 core domain in 94-341p53β-dimer-DNA complex, Δ133p53β-dimer-DNA complex, and Δ160p53β-dimer-DNA complex system. B, C) The RMSD of each 94-341p53β monomer, Δ133p53β monomer (B), and Δ160p53β monomer (C) in the DNA-bound complex. D–F) The superposed structures of 94-341p53β-dimer-DNA complex (D), Δ133p53β-dimer-DNA complex (E), and Δ160p53β-dimer-DNA complex (F). The initial and final snapshots are colored in red and blue, respectively. G–I) Contact probabilities of each amino acid with DNA in the following 3 complexes: 94-341p53β-dimer-DNA complex (G), Δ133p53β-dimer-DNA complex (H), and Δ160p53β-dimer-DNA complex (I).