Figure 9.

Schematic diagram of hypothetical mechanisms leading to Δ133p53β abnormal function and a potential therapeutic strategy. A) Destabilized ∆133p53β has a strong aggregation capability. B) ∆133p53β could prevent p53’s normal function by competing with wt p53 in recognizing p53 response elements. C) The peptide with residues 107–129 of wt p53 could inhibit the aggregation of ∆133p53β and restore ∆133p53β to a wt conformation of p53, and thus potentially re-establish tumor suppressor function.