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. 2018 Dec 19;33(3):4473–4489. doi: 10.1096/fj.201802167R

Figure 4.

Figure 4

CR significantly changed temporal translation in the liver. A) Time-of-day–dependent differential abundance of P-mRNAs in the liver polysomes of AL (blue) and CR (red) animals. Numbers of transcripts were obtained by comparing time points on the x axis with the y axis. Time-dependent effect of CR diet is shown in yellow boxes where AL was compared with CR for the respective time point. Light/dark bar at the top represents light and dark phases of the day. B) Time-dependent effect of CR on P-mRNA abundance in polysomes. Black bars show number of P-mRNA, whose abundance was decreased, and red bars show number of P-mRNAs, whose abundance was increased at a particular time of the day in liver polysome when CR animals were compared with AL animals (n = 2 for every time point for each diet). C) Enriched pathways between AL ZT6-14-18 and AL ZT2-22. D) The enriched pathways between CR ZT18 and CR ZT14. E) Enriched pathways between CR ZT2-6-10-22 and CR ZT14-18. F) Unique enriched pathways between CR and AL at ZT2. G) Unique enriched pathways between CR and AL at ZT14. H) Unique enriched pathways between CR and AL at ZT22. Light is on at ZT0, and off at ZT12.