Figure 1.

SUP-26 promotes embryonic viability in mir-35-41(nDf50). A) A schematic of the principal genetic interactions of sex determination pathway genes in C. elegans. Genes in blue are highly active in the male soma and germline, and the spermatogenic germ cells in hermaphrodites. Genes in red are highly active specifically in the hermaphrodite soma and oogenic germ cells. Germline-specific factors are in boxes. B) Percent lethality at embryonic or early larval stages. sup-26(RNAi) has no effect on wild type, but induces synthetic lethality in mir-35-41(nDf50). C) Percent lethality at embryonic or early larval stages. sup-26(lf) alleles enhance lethality in mir-35-41(nDf50). Mean and standard error for three to four biological replicates are shown.