Table 3.
Risk of incident MCI for SCD and APOE ε4 genotype groups in men
| Risk of incident MCI | SCD− |
SCD+ |
OR (95% CI) for SCD+ within APOE ε4 genotype | ||
|---|---|---|---|---|---|
| Number of no MCI/MCI | OR (95% CI) | Number of no MCI/MCI | OR (95% CI) | ||
| Unadjusted | |||||
| APOE ε4–negative | 338/23 | 1 (reference) | 76/17 | 3.29 (1.66–6.43) | 3.29 (1.66–6.43) |
| group A | group B | P < .001 | P < .001 | ||
| APOE ε4–positive∗ | 107/10 | 1.37 (0.61–2.90) | 29/5 | 2.53 (0.81–6.70) | 1.84 (0.54–5.63) |
| group C | P = .42 | group D | P = .08 | P = .30 | |
| Effect modification: RERI (95% CI) = −1.13 (−4.35 to 2.09), P = .49; multiplicative scale: ratio of ORs (95% CI) = 0.56 (0.14–2.08), P = .40. | |||||
| Adjusted | |||||
| APOE ε4–negative | 338/23 | 1 (reference) | 76/17 | 2.90 (1.43–5.81) | 2.90 (1.43–5.81) |
| group A | group B | P = .003 | P = .003 | ||
| APOE ε4–positive∗ | 107/10 | 1.43 (0.62–3.08) | 29/5 | 2.41 (0.75–6.57) | 1.69 (0.48–5.28) |
| group C | P = .38 | group D | P = .11 | P = .38 | |
| Effect modification: RERI (95% CI) = −0.92 (−4.01 to 2.16), P = .56; multiplicative scale: ratio of ORs (95% CI) = 0.58 (0.14–2.22), P = .43. ORs are adjusted for age, education and depressive symptoms at t2. | |||||
Abbreviations: APOE, apolipoprotein E; CI, confidence interval; MCI, mild cognitive impairment at t2; OR, odds ratio; RERI, relative excess risk due to interaction; SCD (+/−), with and without subjective cognitive decline; t2, second follow-up examination.
NOTE. Risk estimates were calculated by binomial logistic regression analyses and measures of effect modification were assessed for men.
∗
APOE ε4–positive = at least one 4 allele (2/4, 3/4, 4/4).