Table 4.

Key research questions to guide emergency department-based interventions for substance use disorders.

Question 1	What are the most effective, efficient and appropriate ways to screen for SUD in the ED?
Question 2	What are the most effective ED-based interventions for SUDs?
Question 3	What is the role for initiation and management of SUD treatment and detoxification in the ED?
Question 4	What is the role of sociocultural and generational factors in acceptability, accessibility, and benefit of ED-based initiatives?
Question 5	What are the best practices for the evaluation and management of the acutely intoxicated patient?
Question 6	What role can peer mentors, or patient navigators, play in improving patient outcomes?

ED, emergency department; SUD, substance use disorder.