Table 1.

Surviving Sepsis Campaign one-hour bundle.

Bundle element	Grade of recommendation and level of evidence
Measure lactate. Re-measure if initial lactate > 2 mmol/L.	Weak recommendation. Low quality of evidence.
Obtain blood cultures prior to administration of antibiotics.	Best practice statement.
Administer broad-spectrum antibiotics.	Strong recommendation. Moderate quality of evidence.
Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L.	Strong recommendation. Low quality of evidence.
Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥ 65 mm Hg.	Strong recommendation. Moderate quality of evidence.

mmol/L, millimoles per liter; ml/kg, milliliters per kilogram; mmHg, millimeters of mercury; MAP, mean arterial pressure.