Table 2.

Various definitions for sepsis spectral illnesses.

	Sepsis 2.02,3	CMS4	Sepsis-3.05	2016 SCC Guidelines6
SIRS	Temperature > 38°C or < 36°C Heart rate > 90 bpm Respiratory rate > 20 or PaCO2 < 32 mmHg White blood cell count > 12,000/cu mm, < 4,000/cu mm or > 10% bands	No change	Eliminated. qSOFA introduced Respiratory rate > 22 Altered mental status Systolic blood pressure < 90 mmHg	No SIRS. No qSOFA.
Sepsis	Infection and two or more SIRS	No change	Infection and two qSOFA criteria	Infection and end organ dysfunction. No clinical criteria offered.
Severe Sepsis	Sepsis and end organ dysfunction defined as: Sepsis-induced hypotension Lactate above upper limits of laboratory normal Urine output < 0.5 ml/kg/hr × two hours PaO2/FiO2< 250 in absence of pneumonia PaO2/FiO2< 200 in presence of pneumonia Creatinine > 2.0 mg/dL Bilirubin > 2 mg/dL Platelet count < 100,000/uL INR > 1.5	Sepsis and end organ dysfunction. Lactate > 2	Eliminated	Eliminated
Septic Shock	Sepsis and a SBP < 90 mmHg or a reduction of 40 mm Hg from baseline or evidence of low perfusion after adequate fluid bolus.	Initial lactate > 4 or SBP < 90 mm Hg after 30 mL/kg fluid bolus	SBP < 90 mmHg AND lactate > 2 after adequate fluid resuscitation	Subset of sepsis with circulatory and cellular/metabolic dysfunction associated with a higher risk of mortality. No clinical criteria offered

SIRS, systemic inflammatory response syndrome; CMS, Centers for Medicare and Medicaid Services; SCC, Surviving Sepsis Campaign; bpm, beats per minute; cu mm, cubic millimeter; qSOFA, quick sequential organ failure assessment; ml/kg/hr, milliliter per kilogram per hour; PaO₂, partial pressure of oxygen; FiO₂, fraction of inspired oxygen; INR, international normalized ratio; mg/dL, milligram per deciliter; MAP, mean arterial pressure; SBP, systolic blood pressure.

^*All lactate levels in millimoles per liter values.