Axial T1 weighted post-contrast MR (A) and FDG PET/CT images of a patient with a right parieto-occipital GBM demonstrate tumor hypermetabolism on a background of normal, relatively high cerebral metabolism. Axial T1 weighted post-contrast MR (C) and FDOPA PET/CT (D) images of a different patient with GBM show focal FDOPA uptake in a contrast-enhancing nodule along the anterior border of the left frontal tumor resection cavity, indicative of recurrent disease. Of note, different PET display color palettes are used for the example FDG and FDOPA studies. FDG, 18F-Fluorodeoxyglucose; FDOPA, 3,4-dihydroxy-6-18 F-fluoro-l-phenylalanine; GBM, glioblastoma multiforme.