Table 1.
Indications for FDG PET-CT in paediatric malignancies as per current published guidelines
Malignancy | Disease | Published guidelines | |||
EANM 20081 | EANM 20092 | RCR 20143 | RCR 20164 | ||
Haematological | Hodgkin's lymphoma | ✓ | ✓ | # | |
Non-Hodgkin's lymphoma | ✓ | ✓ | # | ||
Extra medullary leukaemia | ✓ | ||||
Langerhans cell histiocytosis | ✓ | ✓ | |||
Nervous system | Neuroblastoma (MIBG negative) | ✓ | ✓ | ✓ | |
Selected brain tumours | ✓ | ✓ | ✓ | # | |
Sarcoma | Osteosarcoma | ✓ | ✓ | ✓ | |
Ewing's sarcoma | ✓ | ✓ | ✓ | ||
Rhabdomyosarcoma | ✓ | ✓ | ✓ | ||
MPNST | ✓ | ✓ | ✓ | ||
Solid organ | Germ cell tumour | ✓ | ✓ | # | |
Hepatoblastoma | ✓ | ✓ | ✓ | ||
Wilms tumour | ✓ | ✓ | ✓ | ||
Other | Malignancy of unknown origin | ✓ | ✓ | ✓ | |
Biopsy target | ✓ | # | |||
Relapse | ✓ | ✓ | ✓ | # |
EANM, European Association of Nuclear Medicine; FDG PET-CT, fluorodeoxyglucose positron emission tomography/CT; MIBG, metaiodobenzylguanidine; MPNST, malignant peripheral nerve sheath tumour; RCR, Royal College of Radiologists.
✓denotes paediatric-specific indication in guidance.
# denotes extrapolated indication from adult guidelines.