Table 4.
Levels of Quantitative Traits at 1 Year by Genotype and Treatment Arm at Loci With a Nominally Significant Interaction
| Gene/Chr/SNP | Alleles | Placebo+Statin | Niacin+Statin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Year 1 | % Change | Absolute Change | Baseline | Year 1 | % Change | Absolute Change | |||||||||
| MAF | Minor/Major | Trait | GT | N | Mean (SD)a | N | Mean (SD) | Mean (SD) | Mean (SD) | N | Mean (SD) | N | Mean (SD) | Mean (SD) | Mean (SD) | |
| MVK | 0.47 | C/T | HDL | TT | 280 | 34.9 (5.4) | 256 | 38.1 (7.9) | 9.1 (15.9) | 3.1 (5.7) | 304 | 34.8 (5.7) | 277 | 45.4 (12.1) | 30.8 (25.3) | 10.7 (9.3) |
| 12 | TC | 474 | 35.4 (5.5) | 435 | 39.1 (7.4) | 10.6 (15.3) | 3.6 (5.3) | 517 | 34.5 (5.4) | 471 | 43.5 (10.6) | 26.4 (23.1) | 9.1 (8.1) | |||
| rs10850443 | CC | 265 | 34.7 (5.4) | 245 | 38.2 (7.2) | 10.5 (16.0) | 3.5 (5.3) | 211 | 34.5 (5.8) | 189 | 43.4 (11.2) | 26.4 (24.1) | 9.0 (8.8) | |||
| P Value by GT | 0.22 | 0.26 | 0.012 | 0.007 | ||||||||||||
| LIPC | 0.36 | A/G | HDL | GG | 404 | 34.6 (5.7) | 376 | 38.2 (7.5) | 11.7 (15.9) | 3.9 (5.3) | 429 | 34.5 (5.8) | 387 | 43.2 (11.5) | 25.8 (23.3) | 8.9 (8.6) |
| 15 | GA | 465 | 35.1 (5.3) | 428 | 38.4 (7.1) | 9.4 (15.3) | 3.2 (5.3) | 472 | 34.5 (5.5) | 430 | 44.5 (11.2) | 29.0 (24.7) | 10.0 (8.6) | |||
| rs1532085 | AA | 151 | 36.1 (5.3) | 133 | 39.6 (8.2) | 8.1 (15.4) | 3.0 (6.0) | 132 | 35.1 (5.3) | 121 | 44.9 (9.7) | 29.2 (23.6) | 10.0 (8.2) | |||
| P Value by GT | 0.006 | 0.026 | 0.037 | 0.031 | ||||||||||||
| PABPC4 | 0.23 | G/A | HDL | AA | 617 | 35.1 (5.4) | 567 | 38.8 (7.3) | 11.0 (5.6) | 3.7 (5.4) | 580 | 34.9 (5.8) | 530 | 44.4 (11.2) | 27.2 (23.5) | 9.4 (8.6) |
| 1 | AG | 361 | 35.3 (5.5) | 332 | 38.3 (7.7) | 9.1 (15.6) | 3.1 (5.5) | 390 | 34.3 (5.4) | 354 | 43.8 (11.3) | 28.4 (24.6) | 9.7 (8.8) | |||
| rs4660293 | GG | 42 | 32.9 (5.8) | 38 | 34.7 (6.3) | 7.3 (16.4) | 2.1 (5.6) | 64 | 34.0 (5.5) | 55 | 43.8 (10.2) | 28.7 (25.0) | 9.7 (8.5) | |||
| P Value by GT | 0.029 | 0.031 | 0.33 | 0.41 | ||||||||||||
| AMPD3 | 0.18 | G/A | HDL | AA | 664 | 35.1 (5.4) | 617 | 38.4 (7.6) | 9.8 (15.9) | 3.3 (5.5) | 698 | 34.6 (5.7) | 633 | 44.2 (11.3) | 28.2 (23.5) | 9.7 (8.6) |
| 11 | AG | 323 | 35.1 (5.7) | 292 | 38.8 (7.3) | 10.9 (15.2) | 3.7 (5.3) | 300 | 34.6 (5.5) | 275 | 43.9 (11.1) | 27.7 (25.5) | 9.5 (8.7) | |||
| rs2923084 | GG | 33 | 33.4 (5.1) | 28 | 36.8 (6.7) | 9.9 (15.9) | 3.2 (5.0) | 36 | 34.9 (5.3) | 31 | 41.2 (9.2) | 18.2 (18.5) | 6.3 (6.9) | |||
| P Value by GT | 0.28 | 0.30 | 0.26 | 0.2 | ||||||||||||
| SPTLC3 | 0.39 | A/G | LDL | GG | 376 | 76.1 (22.8) | 342 | 71.3 (19.1) | −2.7 (28.6) | −5.6 (24.1) | 406 | 74.2 (21.8) | 361 | 68.9 (20.7) | −1.1 (37.4) | −5.4 (25.5) |
| 20 | GA | 482 | 72.3 (21.0) | 448 | 70.6 (18.5) | 1.2 (33.1) | −3.3 (23.9) | 479 | 73.1 (22.5) | 443 | 65.6 (19.8) | −4.5 (38.1) | −8.5 (26.3) | |||
| rs364585 | AA | 162 | 72.4 (22.4) | 144 | 69.2 (7.3) | 1.2 (34.0) | −3.6 (24.5) | 149 | 73.2 (22.5) | 134 | 65.1 (15.1) | −5.2 (37.3) | −9.0 (23.8) | |||
| P Value by GT | 0.08 | 0.22 | 0.11 | 0.043 | ||||||||||||
| TOM1 | 0.34 | A/G | TC | GG | 456 | 144.4 (24.6) | 413 | 143.9 (24.6) | 1.5 (19.6) | −0.7 (29.5) | 462 | 146.2 (27.6) | 422 | 138.8 (27.5) | −3.5 (21.2) | −8.3 (32.0) |
| 22 | GA | 441 | 145.4 (26.4) | 408 | 143.7 (24.4) | 0.8 (19.3) | −1.9 (28.5) | 437 | 142 (25.7) | 392 | 136.5 (26.2) | −1.5 (22.2) | −5.2 (31.4) | |||
| rs138777 | AA | 123 | 149.9 (30.2) | 117 | 144.2 (8.4) | −0.08 (25.7) | −5.5 (38.1) | 135 | 147.3 (36.2) | 128 | 141 (26.4) | −2.2 (21.3) | −6.5 (33.9) | |||
| P Value by GT | 0.35 | 0.38 | 0.14 | 0.12 | ||||||||||||
| PDXDC1 | 0.39 | T/C | TG | CC | 392 | 156 (128, 212) | 365 | 156 (119, 207) | −4 (−23, 21) | −7 (−36, 32) | 359 | 178 (140, 235) | 331 | 117 (85, 160) | −32.0 (−49, −13) | −54 (−97, −21) |
| 16 | CT | 471 | 165 (134, 216) | 431 | 158 (123, 206) | −3 (−26, 24) | −5 (−43, 35) | 516 | 162 (130, 213) | 466 | 120 (83, 171) | −29.4 (−48, −1.5) | −46 (−80, −2) | |||
| rs3198697 | TT | 157 | 173 (136, 222) | 142 | 154 (113, 207) | −9 (−29, 11) | −16 (−47, 20) | 159 | 156 (127, 203) | 145 | 124 (85, 167) | −24.5 (−46, −3) | −38 (−77, −5) | |||
| P Value by GT | 0.13 | 0.077 | 0.034 | 0.015 | ||||||||||||
| CYP26A1 | 0.44 | A/G | TG | GG | 331 | 165 (135, 224) | 306 | 161 (121, 213) | −4 (27, 20) | −7 (−44, 30) | 311 | 165 (129, 225) | 288 | 131 (90, 187) | −23 (−42, 2) | −36 (−76, 3) |
| 10 | GA | 493 | 159 (131, 203) | 451 | 155 (118, 206) | −4 (−23, 22) | −7 (−44, 33) | 525 | 171 (135, 217) | 473 | 114 (82, 161) | −32 (−51, −11) | −54 (−92, −18) | |||
| rs2068888 | AA | 196 | 161 (133, 222) | 181 | 157 (123, 204) | −7 (−27, 21) | −11 (−45, 32) | 198 | 161 (126, 210) | 181 | 115 (83, 157) | −32 (−48, −10) | −48 (−85, −16) | |||
| P Value by GT | 0.40 | 0.59 | <0.0001 | 0.001 | ||||||||||||
Chr indicates chromosome; GT, genotype; HDL, high‐density lipoprotein cholesterol; IQR, interquartile range; LDL, low‐density lipoprotein cholesterol; MAF, minor allele frequency; SNP, single nucleotide polymorphism; TC, total cholesterol; TG, triglycerides.
a
TG reported as median (IQR).