Table 2.
Univariate and Multivariate Logistic Regression Analysis of CRS1 Occurrence in Patients With AMI
| Univariate | Multivariate | |||
|---|---|---|---|---|
| OR (95% CI) | P Value | Adjusted OR (95% CI) | P Value | |
| Age, y | 1.073 (1.057‐1.089) | <0.001 | 1.021 (0.999‐1.045) | 0.065 |
| Female, % | 1.704 (1.241‐2.338) | 0.001 | 0.801 (0.503‐1.276) | 0.350 |
| Hemoglobin at admission, g/dL | 0.969 (0.962‐0.977) | <0.001 | 1.016 (0.974‐1.060) | 0.458 |
| Hematocrit at admission, % | 0.897 (0.874‐0.921) | <0.001 | 0.978 (0.848‐1.128) | 0.763 |
| Albumin at admission, g/dL | 0.892 (0.862‐0.923) | <0.001 | 1.041 (0.986‐1.099) | 0.146 |
| log(NT‐proBNP) at admission | 6.005 (4.524‐7.971) | <0.001 | 2.136 (1.422‐3.209)a | <0.001 |
| eGFR at admission, mL/(min·1.73 m2) | 0.95 (0.943‐0.956) | <0.001 | 0.967 (0.956‐0.979)b | <0.001 |
| Glucose at admission, mmol/L | 1.003 (1.001‐1.005) | 0.002 | 1.003 (1.000‐1.006) | 0.03 |
| hs‐CRP at admission, mg/L | 1.046 (1.035‐1.059) | <0.001 | 1.031 (1.014‐1.048)c | <0.001 |
| Previous coronary artery disease | 1.694 (1.244‐2.307) | 0.001 | 1.067 (0.691‐1.646) | 0.770 |
| Previous hypertension | 1.979 (1.366‐2.867) | <0.001 | 1.378 (0.813‐2.334) | 0.234 |
| Previous diabetes mellitus | 1.562 (1.143‐2.137) | 0.005 | 0.666 (0.397‐1.116) | 0.123 |
| Previous chronic kidney disease | 5.99 (3.916‐9.165) | <0.001 | 1.771 (0.924‐3.396) | 0.085 |
| Angiography after admission | 0.179 (0.131‐0.247) | <0.001 | 0.744 (0.460‐1.202) | 0.227 |
| ACEI and/or ARB after admission | 0.417 (0.306‐0.569) | <0.001 | 0.509 (0.328‐0.789) | 0.003 |
| Diuretics after admission | 4.593 (3.301‐6.391) | <0.001 | 1.811 (1.130‐2.902) | 0.014 |
ACEI indicates angiotensin‐converting enzyme inhibitor; AMI, acute myocardial infarction; ARB, angiotensin receptor blocker; CI, confidence interval; CRS1, cardiorenal syndrome type 1; eGFR, estimated glomerular filtration rate; hs‐CRP, high sensitivity C‐reactive protein; NT‐proBNP, amino‐terminal pro–brain natriuretic peptide; OR, odds ratio.
a
The odds ratio and 95%CI for 1 standard deviation change in the logNT‐proBNP were 1.792 (1.311–2.450).
b
The odds ratio and 95%CI for 1 standard deviation change in the eGFR was 0.424 (0.310–0.576).
c
The odds ratio and 95%CI for 1 standard deviation change in the hs‐CRP was 1.429 (1.180–1.747).