Table 4.

Prematching Receiver Operating Characteristic Curve Analysis of NT‐proBNP, eGFR, and hs‐CRP Adjusted by Covariates for the Prediction of CRS1

	AUC	P Value	95% CI
Covariates	0.837	<0.001	0.804 to 0.870
eGFR+ covariates	0.866	<0.001	0.850 to 0.881
Log(NT‐proBNP)+covariates	0.858	<0.001	0.824 to 0.892
hs‐CRP+ covariates	0.849	<0.001	0.832 to 0.865
Log(NT‐proBNP)+eGFR+hs‐CRP+covariates	0.882	<0.001	0.850 to 0.913

The covariates included age, sex, hemoglobin, hematocrit, albumin, glucose, previous coronary artery disease, previous hypertension, previous diabetes mellitus, previous chronic kidney disease, angiography, ACEI and/or ARB use after admission, and diuretic use after admission. The differences in the AUC values adjusted by covariates between the individual biomarkers and their combinations were statistically significant, with P values of 0.0330 (eGFR+covariates vs Log[NT‐proBNP]+eGFR+hs‐CRP+covariates), 0.0070 (Log[NT‐proBNP]+covariates vs Log[NT‐proBNP]+eGFR+hs‐CRP+covariates), 0.0062 (hs‐CRP+covariates vs Log[NT‐proBNP]+eGFR+hs‐CRP+covariates), and 0.0008 (covariates vs Log[NT‐proBNP]+eGFR+hs‐CRP+covariates). ACEI indicates angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; AUC, area under the receiver operating characteristic curve; CI, confidence interval; CRS1, cardiorenal syndrome type 1; eGFR, estimated glomerular filtration rate; hs‐CRP, high‐sensitivity C‐reactive protein; NT‐proBNP, amino‐terminal pro–brain natriuretic peptide.