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. 2018 Sep 29;7(19):e010427. doi: 10.1161/JAHA.118.010427

Figure 1.

Figure 1

High‐confidence interaction among extracellular matrix (ECM)–related proteins and greater fibrosis in adult dilated cardiomyopathy (DCM) hearts compared with pediatric DCM hearts. A, STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) analysis shows high‐confidence interaction clusters (k‐means=5 clusters indicated by node color) formed by ECM‐related proteins. B through D, Representative images of Picrosirius Red (PSR) (B) and Masson trichrome–stained (C) left ventricular free wall from pediatric and adult control and DCM myocardium. Scale bar: 100 μm. D, Averaged quantification of collagen content (from PSR‐stained sections) in indicated groups (mean±SEM). n=6 hearts per group. *P<0.05 compared with the corresponding control, † P<0.05 compared with the corresponding pediatric group. ADAM indicates a disintegrin and metalloprotease; ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; AFU, arbitrary fluorescence units; BGN, biglycan; COL, collagen; DCN, decorin; LUM, lumican; MMP, matrix metalloprotease; NFC, nonfailing control; OGN, osteoglycan; SGCG, sarcoglycan gamma; SPARC, secreted protein acidic and cysteine‐rich; THBS1, thrombosondin‐1; TIMP, tissue inhibitors of metalloprotease; TNXB, tenascin x; VCAN, versican.