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. 2018 Sep 29;7(19):e010427. doi: 10.1161/JAHA.118.010427

Figure 7.

Figure 7

Proteolytic activities of matrix metalloproteases (MMPs) in control and failing hearts of pediatric and adult populations. A, Total MMP activity, measured using a fluorescent‐based in vitro activity assay, in the indicated groups. B, A Representative gelatin zymogram showing MMP‐9 and MMP‐2 levels in nonfailing control (NFC) and dilated cardiomyopathy (DCM) hearts from pediatric and adult groups. Coomassie blue (CBB)–stained SDS‐PAGE was used as the loading control. C, Quantification of gelatinolytic activities for (i) proMMP9, (ii) proMMP2, and (iii) MMP2. n=12 to 16 per group. Data represent mean±SEM. *P<0.05 compared with the corresponding control, P<0.05 compared with the corresponding pediatric group. AU indicates arbitrary units.