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. 2018 Sep 29;7(19):e010427. doi: 10.1161/JAHA.118.010427

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Altered tissue inhibitors of metalloprotease (TIMP) levels in nonfailing control (NFC) and dilated cardiomyopathy (DCM) hearts from pediatric and adult populations. Representative Western blots (A) and averaged protein quantification (B) for TIMP1, TIMP2, TIMP3, and TIMP4. n=12 to 16 per group. Data represent median±interquartile range. (C) A collective array showing a summary of protein expression levels for the molecules analyzed in this study in pediatric and adult NFC and DCM hearts. The color scale indicates the relative expression level. *P<0.05 compared with the corresponding control, ^† P<0.05 compared with the corresponding pediatric group. ADAMS indicates A disintegrin and metalloproteinases; ADAMTSs, a disintegrin and metalloproteinase with thrombospondin motifs; AU, arbitrary units; MMPs, matrix metalloproteases; sGAGs, sulfated glycosaminoglycans; SPARC, secreted protein acidic and cysteine‐rich; THBS1, thrombosondin‐1.