Table 2.
All‐Cause Mortality Predictive Model Covariates—Univariate and Selection Model ORs
| Baseline Characteristic | OR Comparison | Unadjusted OR (95% CI) | Unadjusted P Value | Selection Model OR (95% CI) | Selection Model P Value |
|---|---|---|---|---|---|
| Age, y | Per 5 y | 1.38 (1.34, 1.43) | <0.001 | 1.32 (1.26, 1.37) | <0.001 |
| Sex | Female vs male | 0.65 (0.57, 0.74) | <0.001 | 0.69 (0.60, 0.80) | <0.001 |
| Ethnicity | Hispanic or Latino vs non‐Hispanic | 0.93 (0.79, 1.09) | 0.372 | ||
| Race | American Indian or Alaska Native vs white | 1.01 (0.38, 2.70) | 0.228 | ||
| Asian vs white | 0.72 (0.57, 0.93) | ||||
| Black vs white | 1.02 (0.80, 1.31) | ||||
| Native Hawaiian or other Pacific Islander vs white | 1.08 (0.35, 3.34) | ||||
| Other vs white | 0.95 (0.76, 1.20) | ||||
| Region | Asian Pacific vs North America | 0.64 (0.50, 0.84) | 0.006 | 0.84 (0.63, 1.11) | 0.014 |
| Europe vs North America | 1.01 (0.88, 1.16) | 1.10 (0.95, 1.29) | |||
| Latin America vs North America | 0.97 (0.80, 1.17) | 1.31 (1.05, 1.62) | |||
| Smoking status | Current vs never | 1.41 (1.18, 1.69) | <0.001 | 1.72 (1.41, 2.10) | <0.001 |
| Former vs never | 1.35 (1.19, 1.53) | 1.12 (0.97, 1.28) | |||
| Alcohol consumption | Yes vs no | 0.90 (0.79, 1.02) | 0.088 | ||
| Previous cardiovascular event | Yes vs no | 2.90 (2.45, 3.44) | <0.001 | 1.59 (1.29, 1.95) | <0.001 |
| Previous MI | Yes vs no | 2.01 (1.78, 2.27) | <0.001 | 1.39 (1.21, 1.60) | <0.001 |
| Diabetes mellitus duration | Per 5 y | 1.16 (1.12, 1.19) | <0.001 | ||
| Previous revascularization | Yes vs no | 1.57 (1.40, 1.77) | <0.001 | 0.85 (0.74, 0.99) | 0.033 |
| Cerebrovascular disease | Yes vs no | 1.74 (1.52, 1.99) | <0.001 | 1.27 (1.10, 1.48) | 0.001 |
| NYHA class | I vs no HF | 2.01 (1.61, 2.52) | <0.001 | 1.55 (1.23, 1.95) | <0.001 |
| II vs no HF | 2.57 (2.19, 3.01) | 1.78 (1.50, 2.12) | |||
| III vs no HF | 4.31 (3.38, 5.51) | 2.58 (1.99, 3.36) | |||
| IV vs no HF | 16.90 (8.03, 35.57) | 8.27 (3.66, 18.65) | |||
| Chronic liver disease | Yes vs no | 1.27 (0.96, 1.66) | 0.092 | ||
| Chronic respiratory disease | Yes vs no | 1.77 (1.49, 2.10) | <0.001 | 1.27 (1.06, 1.53) | 0.010 |
| Hyperlipidemia | Yes vs no | 1.08 (0.93, 1.25) | 0.321 | 0.82 (0.70, 0.96) | 0.016 |
| Hypertension | Yes vs no | 1.98 (1.61, 2.44) | <0.001 | 1.35 (1.08, 1.69) | 0.009 |
| Atrial fibrillation | Yes vs no | 2.34 (1.98, 2.78) | <0.001 | 1.33 (1.11, 1.60) | 0.002 |
| Unstable angina | Yes vs no | 1.33 (1.06, 1.66) | 0.013 | ||
| Depression | Yes vs no | 1.00 (0.84, 1.20) | 0.990 | ||
| BMI | Per 1 point, under 30 | 0.94 (0.91, 0.97) | <0.001 | 0.93 (0.91, 0.96) | <0.001 |
| Per 1 point, over 30 | 1.01 (1.00, 1.03) | 1.03 (1.02, 1.05) | |||
| HbA1c | Per 1% | 1.05 (0.99, 1.12) | 0.131 | 1.13 (1.06, 1.20) | <0.001 |
| eGFR | Per 10 mL/min/1.73 m2, under 85 | 0.76 (0.73, 0.79) | <0.001 | 0.86 (0.82, 0.90) | <0.001 |
| Per 1 mL/min/1.73 m2, over 85 | 1.02 (0.96, 1.08) | 1.07 (1.03, 1.12) | |||
| SBP | Per 10 mm Hg, under 130 | 0.86 (0.79, 0.93) | <0.001 | ||
| Per 10 mm Hg, over 130 | 1.09 (1.04, 1.15) | ||||
| DBP | Per 10 mm Hg, under 85 | 0.73 (0.68, 0.78) | <0.001 | 0.87 (0.80, 0.94) | 0.001 |
| Per 10 mm Hg, over 85 | 1.19 (1.00, 1.41) | 1.20 (1.00, 1.45) | |||
| Pulse pressure | Per 10 mm Hg, under 50 | 0.96 (0.84, 1.09) | <0.001 | ||
| Per 10 mm Hg, over 50 | 1.16 (1.11, 1.22) |
BMI indicates body mass index; CI, confidence interval; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; MI, myocardial infarction; NYHA, New York Heart Association; OR, odds ratio; SBP, systolic blood pressure.