FIG. 1.

Overview of the microfluidic centrifugal nanoparticles separation and extraction (μCENSE) platform. (a) Schematic of the centrifugal microfluidic chip. It consists of one inlet, two outlets, and a separation channel. The scale bar represents 5 mm. The inset describes the separation principle: centrifugal force drives fluid pressure along the separation channel and radial force pushes the particles away from the center of rotation by size. (b) Rotor assembly allowing multiple microfluidic chips to be held in place during centrifugation. The scale bar represents 15 mm. (c) Actual fabricated centrifugal microfluidic platform. The scale bar represents 50 mm. (d) Photograph depicting loading of the sample fluid via a micropipette and the movement of the red dye. The arrow indicates the position of the dye at different centrifugal intervals (t = 0 s, 30 s, and 60 s).