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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Drug Alcohol Depend. 2018 Jul 7;191:14–24. doi: 10.1016/j.drugalcdep.2018.05.029

Figure 2.

Figure 2.

Precipitated THC withdrawal affects emotionality and induces somatic alterations. Male mice were administered THC (1, 10 or 50 mg/kg) or JWH-018 (1 mg/kg) for 6 days and withdrawal was induced with the CB1 selective antagonist rimonabant (3 mg/kg) 30 min prior to testing. THC (10 or 50 mg/kg) withdrawal increased paw tremors and head twitches (A), THC (10 or 50 mg/kg) or JWH-018 (1 mg/kg) increased struggling in the tail suspension test (B), and THC (1, 10 or 50 mg/kg) or JWH-018 (1mg/kg) decreased marbles buried (C). THC (1 mg/kg) increased time immobile in marble burying, while THC (50 mg/kg) withdrawal decreased time spent immobile (D). Data represent mean ± SEM (n = 7–12/group). *p < 0.05 vs. corresponding non-rimonabant control.