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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Drug Alcohol Depend. 2018 Jul 7;191:14–24. doi: 10.1016/j.drugalcdep.2018.05.029

Figure 5.

Figure 5.

Spontaneous THC withdrawal increases somatic signs of withdrawal. Male and female mice were administered THC (10 or 50 mg/kg) or JWH-018 (1 mg/kg) for 6 days. Spontaneous withdrawal was evaluated at various time points after the final THC injection. At 24 h post-injection, males treated with THC (50 mg/kg) had increased paw tremors (A) and head twitches (B). At 36 h post-injection, males treated with THC (10 mg/kg) or JWH-018 exhibited increased paw tremors and at 24 and 36 h post-injection head twitches increased. No changes were observed in male hind leg scratching (C). Similarly, females treated with THC (10 or 50 mg/kg) or JWH-018 displayed increased paw tremors (D) and head twitches (E) at 36 h. Females treated with THC (50 mg/kg) showed increased hind leg scratching at 6 and 24h post-injection (F). Data represent mean ± SEM (n = 7–8/group) *p < 0.05 vs. vehicle control.