Fig. 26.

(A) Flourescein angiogram of the macula of a normal eye using a confocal scanning laser ophthalmoscopic system. The parafoveal capillaries and the foveal avascular zone may be discerned, but the capillary circulation outside this region are not evident. (B) Fluorecein angiographic image of an eye with a classic choroidal neo-vascularization (CNV). Although hyperfluroescence from the vascular lesion is evident, the microvascular network of the CNV lesion is not apparent. Leakage of dye, however, is evident. (C) Widefield fluorescein angiographic image (Optos 200Tx) of an eye with diabetic retinopathy. The eripheral non-perfusion temporally can be recognized by the absence of the large vessels and the feature-less appearance of the retina. The capillary circulation outside of the central macula is not evident. Multiple small areas of retinal neovascularization are identified by the hyperfluorescent leakage of dye, but the fine vessels of the neovascular tufts cannot be seen.