Table 2:

Dose modification during PIPAC therapy.

Adverse reaction	Action
Grade 1	No modification
Grade 2	If the toxicity is tolerable for the patient, the planned treatment will continue. If the toxicity is poorly tolerated, the dose of oxaliplatin will be reduced to 75 %.
Grade 3	The treatment will be postponed until the toxicity is below grade 2. After this, oxaliplatin can be given in a dose of 75 %.
Grade 4	Stop treatment. Treatment can be reinstituted at the discretion of the responsible physician, if the adverse reaction falls below grade 2