Table 1:

Overview of experimental interventions.

	Study period
	Enrollment	Allocation	Postallocation									Follow-up
Time point	Preoperative	0 week	1 week	2 weeks	3 weeks	5 weeks	6 weeks	7 weeks	9 weeks	10 weeks	11 weeks	17 weeks	35 weeks
Enrollment
Eligibility screen	x
Informed consent	x
Allocation		x
Interventions
PIPAC 1			x
PIPAC 2						x
PIPAC 3									x
Assessments
Blood sampling for toxicity		x	x			x			x
Blood sampling for PK modelling			x			x			x
Tumor biopsies for PK modelling			x			x			x
Blood sampling for PD modelling		x	x	x		x	x		x	x
Quality of life		x			x			x			x	x	x
Pain score		x	x	x		x	x		x	x