Table 1:
Summary of studies included.
| Author | Year | Type | FIGO stage |
N pat | N PDS | N CR | CR/ PDS (%) |
N futile lap | Futile lap/patients | Cut-off for futile laparotomy | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Rutten | 2017 | Randomized controlled trial | IIb and higher | *102 | 63 | 53 | 84% | 10 | 10 % | Tumour > 1 cm |
| 2 | Petrillo | 2015 | Retrospective | AOC | 234 | 234 | 189 | 81 % | 45 | 19 % | Tumour > 1 cm |
| 3 | Fagotti | 2005 | Prospective | AOC (18 % I-II) | 95 | 64 | 38 | 59 % | 26† | 27 % | Tumour > 1 cm |
| 4 | Fagotti | 2008 | Prospective | AOC | 113 | 113 | 56 | 50 % | 57 | 50 % | Tumour > 1 cm |
| 5 | Brun | 2008 | Retrospective | AOC | 55 | 26 | 18 | 69 % | 8 | 15 % | Tumour > 1 cm |
| 6 | Brun | 2009 | Same population as Brun 2008 | ||||||||
| 7 | Vergote | 1998 | Retrospective | AOC | 77 | 28 | 21 | 75 % | 7 | 9 % | Tumour > 0.5 cm |
| 8 | Angioli | 2005 | Not reported | IIIc/IV | 87 | 53 | 51 | 96 % | 2 | 2 % | No tumour visible |
| 9 | Deffieux | 2006 | Not reported | IIIc/IV | 15 | 11 | 10 | 91 % | 1 | 7 % | Tumour > 1 cm |
| 778 | 592 (76 % patients) | 436 (56 % PDS) | 50 to 91 % | 156 (20 % patients) | 2 to 50 % | ||||||
Legend: AOC: Advanced ovarian cancer; LS: laparoscopic staging; PDS: Primary debulking surgery; CR: complete cytoreduction; *: LS group only; 39 % futile laparotomy after conventional staging, 10 % after LS, RR 0.25 (95 % CI: 0.13–0.47, p<0.001); in Fagotti 2004 CR status remained undefined in 13 patients; †: N/A: not available; TP: true positive; FP: false positive; FN: false negative; TN: true negative.