Table 1:
Summary of the parameters that are involved in the drug transport during intraperitoneal chemotherapy. The parameters are subdivided in three main categories: therapy related, drug related and tumour tissue related.
| Therapy related | Drug related | Tumour tissue related |
|---|---|---|
| Dose | Molecular weight | Permeability |
| Temperature | Ionic charge | Vascularity |
| Carrier fluid | Membrane binding | Interstitial fluid pressure (IFP) |
| Volume of carrier fluid | Solubility | Cell density |
| Intra-abdominal pressure | Diffusivity | Extracellular matrix composition |
| Vaso-active agents | ||
| Surfactant use | ||
| Duration |