Table 1. Clinical characteristics of DM1 and DM2 patients and controls at baseline (T1) and follow-up (T2).
| DM1 | DM2 | Controls | ||||
|---|---|---|---|---|---|---|
| T1 | T2 | T1 | T2 | T1 | T2 | |
|
n Sex (M/F) |
16 6/10 |
16 9/7 |
17 9/8 |
|||
| Age, given in years |
42.5 ± 6.5 (30.8–56.0) |
48.2 ± 6.5 (36.7–61.9) |
48.5 ± 8.4 (38.4–64.6) |
53.8 ± 8.3 (43.4–69.6) |
50.5 ± 9.8 (33.5–67.9) |
56.2 ± 9.7 (39.4–72.9) |
| Time interval, given in years | 5.8 ± 0.3 | 5.2 ± 0.5 | 5.7 ± 0.2 | |||
| CTG repeat length | 618.1 ± 284.1 (180–1200) |
- | - | |||
| Educational level, sum score | 11.3 ± 1.8 (8–14) |
11.3 ± 2.4 (8–14) |
12.1 ± 1.5 (9–14) |
|||
| Duration of disease, given in years | 13.4 ± 7.5 (2–25) |
19.1 ± 7.6 (7–31) |
11.4 ± 9.1 (1–36) |
16.9 ± 9.1 (6–41) |
- | - |
| Severity of disease, Muscular Impairment Rating Scale | 3.4 ± 1.0 (2–5) |
3.9 ± 0.6 (3–5) |
- | - | - | - |
| Fine motor skills, Purdue Pegboard bim., cut off <11 pairs in 30s |
10 ± 2.5 (5–14) |
8.4 ± 3.6 (2–13) |
10.6 ± 2.1 (7–13) |
10.0 ± 1.6 (7–13) |
11.5 ± 1.3 (9–14) |
10.9 ± 1.7 (7–13) |
| BDI Score |
7.8 ± 5.1 (1–20) |
9.4 ± 4.3 (2–18) |
8.5 ± 6.7 (0–24) |
10.9 ± 7.6 (1–26) |
1.9 ± 3.5 (0–13) |
3.0 ± 2.9 (0–9) |
| Depression, absolute number of participants with a BDI score above cut off (>10) | 5 | 5 | 6 | 7 | 1 | 0 |
Given values are mean ± SD (otherwise indicated differently), range values are given in brackets.
T1 = baseline examination, T2 = follow-up examination, M = male, F = female
Educational levels were assessed as a combination score of graduation and professional qualification (sum score).
Purdue Pegboard bimanual: lower values correspond to a worse test result.
BDI: Beck Depression Inventory, original version, to assess depressive symptoms (BDI sum score <10: normal or clinically inapparent, 10–19: mild depression, 20–29: moderate depression, >29: severe depression) [30].
Bold = significant difference compared with control group, p < 0.05