Table 2. Genotype and allelic distribution of rs243865 MMP-2 polymorphism in age-related macular degeneration patients and healthy subjects.

Authors, year	Subject groups	N	Genotype distribution				Allele distribution
			CC	CT	TT	CT+TT	C	T
Cheng et al., 2017	AMD patients	126	94	27	5	32	215	37
	Healthy subjects	141	89	42	10	52	220	62
	AMD patients < 65 y	53	40	N/A	N/A	13	N/A	N/A
	Healthy controls < 65 y	76	49	N/A	N/A	27	N/A	N/A
	AMD patients > 65 y	73	54	N/A	N/A	19	N/A	N/A
	Healthy controls > 65 y	65	40	N/A	N/A	25	N/A	N/A
Liutkeviciene et al., 2016	AMD patients	387	229	132	26	158	590	184
	Healthy controls	682	385	252	45	297	1022	342
	AMD patients < 65 y	181	118	48	15	63	284	78
	Healthy controls < 65 y	306	186	103	17	120	475	137
	AMD patients > 65 y	206	111	84	11	95	306	106
	Healthy controls > 65 y	376	199	149	28	177	547	205
Ortak et al., 2013	AMD patients	144	80	60	4	64	220	68
	Healthy controls	172	108	64	0	64	280	64
Seitzman et al., 2008	ADM patients	434	N/A	N/A	N/A	N/A	660	208
	Healthy controls	456	N/A	N/A	N/A	N/A	678	234
Liutkeviciene et al., 2017	ADM patients	324	191	112	21	133	494	154
	Healthy controls	526	289	198	39	237	776	276
Liutkeviciene et al., 2018	AMD patients	267	157	84	26	110	398	136
	Healthy controls	318	190	108	20	128	488	148
	AMD patients < 65 y	99	56	35	8	43	147	51
	Healthy controls < 65 y	113	69	39	5	44	177	49
	AMD patients > 65 y	168	101	49	18	67	251	85
	Healthy controls > 65 y	205	121	69	15	84	311	99

MMP-2, matrix metalloproteinase-2 gene; AMD, age-related macular degeneration; y, years of age; N/A, not available