Table 2. Differentially expressed genes with high fold-change (>4.0) for HRSV group in comparison with HRV group.
| Gene | Gene expression average | FC* | Adj p | Functional description | |
|---|---|---|---|---|---|
| HRSV group | HRV group | HRSV/HRV | |||
| C14orf162 | 2602.4 | 160.0 | 16.3 | 0.02 | aliase CCDC177; coiled-coil domain containing 177 |
| ZDHHC20 | 556.4 | 66.1 | 8.4 | 0.00 | palmitoyltransferase activity |
| FAM118A | 6773.3 | 999.9 | 6.8 | 0.00 | protein binding |
| TTC28 | 2678.2 | 401.9 | 6.7 | 0.00 | cell division |
| ZNF2a | 6052.0 | 910.6 | 6.6 | 0.00 | regulation of transcription, DNA-templated |
| ZSCAN2 | 3203.1 | 482.2 | 6.6 | 0.00 | regulation of transcription, DNA-templated |
| POLR2J2 | 3675.9 | 587.7 | 6.3 | 0.00 | transcription, DNA-templated |
| TBXA2R | 4479.4 | 759.7 | 5.9 | 0.00 | G-protein coupled receptor signaling pathway; inflammatory response |
| KIAA1875 | 13424.5 | 2329.1 | 5.8 | 0.00 | aliase WDR97; WD repeat domain 97; function unkhown |
| COX6B2 | 22173.3 | 4028.8 | 5.5 | 0.00 | protein binding; mitochondrial crista |
| LOC284454 | 2120.3 | 412.8 | 5.1 | 0.01 | ncRNA |
| SOX13 | 509.6 | 102.7 | 5.0 | 0.01 | DNA-binding transcription factor activity |
| LAG3 | 408.5 | 82.7 | 4.9 | 0.00 | MHC class II protein binding; positive regulation of natural killer cell mediated cytotoxicity |
| HYAL4 | 7786.2 | 1615.4 | 4.8 | 0.00 | glycosaminoglycan catabolic process |
| ZNF713 | 9430.2 | 1961.7 | 4.8 | 0.01 | regulation of transcription, DNA-templated |
| EVX1b | 2108.4 | 445.8 | 4.7 | 0.00 | regulation of transcription, DNA-templated |
| SERPING1 | 148.5 | 32.4 | 4.6 | 0.04 | complement activation, classical pathway |
| WDR90 | 1029.3 | 244.6 | 4.2 | 0.00 | WD repeat domain 90; protein binding |
| LGALS3BPb | 1167.2 | 286.0 | 4.1 | 0.00 | cellular defense response; receptor-mediated endocytosis |
| MOCS3 | 4127.3 | 1026.0 | 4.0 | 0.00 | Mo-molybdopterin cofactor biosynthetic process |
| AMN | 966.0 | 242.7 | 4.0 | 0.00 | receptor-mediated endocytosis |
| SIRPB1 | 109.8 | 607.9 | -5.5 | 0.02 | neutrophil degranulation |
agene also is HGS-hub of the HRV group
bgenes also are HGS-hub of the HRSV group
*FC, fold-change was calculated by the ratio of gene expression median in HRSV/HRV groups. The comparison was done using t-test with adjusted Bonferroni correction (p<0.05 was considered significant).