Table 3. Functional description of the HGS-hub genes in modules highly and positively associated with HRSV group.
| ME | Gene | FCa | GO terms or PubMed | Biological function |
|---|---|---|---|---|
| Midnight blue | CCNA2 | 2.62 | positive regulation of transcription, DNA-templated; viral process | transcription/viral process |
| MED6 | 1.19 | regulation of transcription by RNA polymerase II | transcription | |
| PPP2R1B | 1.36 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | apoptosis | |
| PGRMC2 | 1.39 | protein binding | protein binding | |
| CD28 | 1.51 | positive regulation of inflammatory response to antigenic stimulus | inflammatory response | |
| TPX2 | 2.20 | apoptotic process | apoptosis | |
| HIST1H1B | 2.03 | histone deacetylase binding | transcription | |
| FEN1 | 1.67 | double-strand break repair | replication | |
| CCNB1 | 1.81 | histone H3-S10 phosphorylation involved in chromosome condensation | epigenetic process | |
| PDCD1 | 1.70 | positive regulation of T cell apoptotic process | apoptosis | |
| KIF23 | 1.90 | antigen processing and presentation of exogenous peptide antigen via MHC class II | immune response | |
| CXCR6 | 2.42 | chemokine-mediated signaling pathway; inflammatory response | inflammatory response | |
| NPEPL1 | 0.74 | aminopeptidase activity | metabolic process | |
| SLC25A16 | 0.57 | mitochondrial transport | mitochondrion | |
| LOC388242 | 0.43 | pseudogene | ND | |
| TSPAN32 | 0.60 | cell surface receptor signaling pathway | signaling | |
| ANKRD13D | 0.73 | late endosome [19] | ubiquitination | |
| Turquoise | PFDN1 | 1.17 | regulation of transcription, DNA-templated | transcription |
| CSNK2B | 1.29 | macroautophagy; neutrophil degranulation | autophagic process | |
| DCST2 | 3.89 | codifies a dendritic cell-specific transmembrane protein | immune response | |
| LGALS3BP | 4.23 | cell adhesion; cellular defense response; receptor-mediated endocytosis | immune response/antiviral response | |
| FAM48A | 1.82 | alias SUPT20H; regulation of transcription by RNA polymerase II | transcription | |
| YWHAQ | 1.49 | negative regulation of transcription, DNA-templated | transcription | |
| HIST1H2AM | 1.63 | chromatin organization | transcription | |
| B4GALT2 | 2.18 | galactosyltransferase activity | metabolic process | |
| TMEM160 | 1.57 | integral component of membrane | protein binding | |
| HIST2H2AC | 1.83 | chromatin organization | transcription | |
| RNASEH2A | 1.58 | DNA replication | replication | |
| EVX1 | 4.89 | positive regulation of transcription from RNA polymerase II promoter | transcription | |
| PFKP | 1.29 | glucose catabolic process | metabolic process | |
| CCDC84 | 0.70 | coiled-coil domain protein | ND | |
| EFNB1 | 0.43 | ephrin receptor signaling pathway; T cell costimulation | immune response | |
| BTAF1 | 0.62 | negative regulation of transcription, DNA-templated | transcription | |
| TRIT1 | 0.62 | mitochondrial tRNA modification | mitochondion | |
| DENND4B | 0.63 | regulation of Rab protein signal transduction | signaling | |
| ZMIZ2 | 0.59 | positive regulation of transcription by RNA polymerase II | transcription | |
| RNASEH2C | 0.65 | RNA catabolic process | Rnase | |
| C19orf6 | 0.54 | aliase TMEM259; codifies an aspecific BCL2 ARE-binding protein 1 | ER | |
| GUSB | 0.69 | carbohydrate metabolic process | metabolic process | |
| Tan | TRAFD1 | 1.60 | response to cytokine | inflammatory response |
| APOL1 | 2.09 | cytolysis; killing of cells of other organisms | immune response/antiviral response | |
| IDO1 | 3.81 | NOT regulation of activated T cell proliferation | immune response |
aFC, HRSV/HRV fold-change >1.0 –hyper-expressed genes or < 1.0—hypo-expressed genes
ME–module eigengene.