Table 4. Functional description of the HGS-hub genes in modules highly and positively associated with HRV group.
| ME | Gene | FCa | GO terms or PubMed | Biological function |
|---|---|---|---|---|
| Purple | STK11IP | 1.54 | neutrophil degranulation | immune response |
| PPP1R16A | 1.54 | regulation of phosphoprotein phosphatase activity | metabolic process | |
| FRY | 1.99 | microtubule organizing center | microtubule | |
| TPPP3 | 2.80 | microtubule bundle formation | microtubule | |
| EFEMP2 | 2.09 | calcium ion binding; extracellular matrix organization | matrix organization | |
| KCNQ1 | 1.77 | calmodulin binding | ion transport | |
| RASSF2 | 1.36 | negative regulation of NIK/NF-kappaB signaling; positive regulation of apoptotic process | apoptosis | |
| ZNF562 | 1.30 | regulation of transcription, DNA-templated | transcription | |
| CHP | 1.48 | negative regulation of NF-kappaB transcription factor activity | immune response | |
| MSRA | 1.46 | response to oxidative stress | metabolic process | |
| RCOR1 | 1.76 | histone H4 deacetylation; viral process | transcription/viral process | |
| UHRF1BP1 | 1.56 | histone deacetylase binding | epigenetic process | |
| WDFY2 | 1.67 | positive regulation of protein phosphorylation | ion binding | |
| H3F3A | 1.28 | histone binding | transcription | |
| CCDC88A | 1.83 | TOR signaling | autophagic process | |
| GBE1 | 1.70 | glucose metabolic process | metabolic process | |
| CBL | 2.12 | ephrin receptor binding | inflammatory response | |
| SLC16A5 | 1.54 | monocarboxylic acid transport | metabolic process | |
| TNFRSF4 | 0.57 | positive regulation of T cell cytokine production | inflammatory response | |
| SLC38A5 | 0.48 | amino acid transport | protein transport | |
| IGSF8 | 0.70 | protein binding; cell motility; immunoglobulin protein superfamily; cell migration and viral infection | immune response/antiviral response | |
| FTSJ3 | 0.79 | rRNA methyltransferase activity | transcription | |
| HAX1 | 0.81 | interleukin-1 binding; negative regulation of apoptotic process | anti-apoptosis | |
| CCDC101 | 0.70 | histone H3 acetylation; SAGA complex; SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing [20] | antiviral response | |
| PSMC4 | 0.85 | antigen processing and presentation of peptide antigen via MHC class I; apoptosis | immune response | |
| MRPL49 | 0.73 | mitochondrial translation | translation | |
| Brown | ZDHHC8 | 1.66 | regulation of mitochondrion degradation | mitochondrion |
| PTAR1 | 1.59 | protein prenylation | metabolic process | |
| FAM122B | 1.50 | ND | ND | |
| VHL | 1.51 | negative regulation of apoptotic process; ubiquitin protein ligase activity | anti-apoptosis | |
| TSC1 | 1.85 | GTPase regulator activity; cell-matrix adhesion | cell adhesion | |
| IFT172 | 1.54 | Notch signaling pathway | inflammatory response | |
| PACS2 | 2.74 | autophagosome assembly; apoptotic process | autophagic process | |
| SLTM | 1.71 | apoptotic process | apoptosis | |
| ASCC1 | 1.31 | DNA repair | DNA repair | |
| SLC12A6 | 1.73 | protein kinase binding | protein binding | |
| HIPK1 | 1.74 | extrinsic apoptotic signaling pathway | apoptosis | |
| TMEM107 | 1.46 | cilium assembly | cytoskeleton/cilium | |
| REEP5 | 1.35 | protein binding | protein binding | |
| TBC1D9 | 1.84 | GTPase activator activity | GTPase | |
| CROCC | 1.39 | actin cytoskeleton | cytoskeleton/cilium | |
| MLL | 1.44 | chromatin modifying enzymes | transcription | |
| CBR4 | 1.74 | oxidation-reduction process | Redox | |
| TMEM129 | 1.70 | ubiquitin protein ligase activity | Ubiquitin | |
| POP1 | 1.34 | tRNA processing | translation | |
| SNAPC4 | 1.46 | chromatin binding | transcription | |
| ZADH2 | 1.58 | oxidation-reduction process | Redox | |
| FBXO41 | 1.62 | ubiquitin-protein transferase activity | Ubiquitin | |
| CTNNB1 | 0.83 | transcription elongation from RNA polymerase II promoter | transcription | |
| DYNLRB1 | 0.68 | SMAD binding; cell-matrix adhesion | cell adhesion | |
| ZDHHC24 | 0.77 | microtubule motor activity | microtubule | |
| GTF2B | 0.72 | regulation of transcription, DNA-templated | transcription | |
| ZFR | 0.80 | pyruvate metabolic process | metabolic process | |
| ZNF2 | 0.15 | protein transmembrane transport | protein transport | |
| TIMM17B | 0.75 | protein-cysteine S-palmitoyltransferase activity | metabolic process | |
| ADRM1 | 0.76 | poly(A) RNA binding | translation | |
| PDHX | 0.71 | transcription, DNA-templated | transcription |
aFC, HRV/HRSV fold-change >1.0 –hyper-expressed genes or < 1.0—hypo-expressed genes
ME–module eigengene.