Table 2. Salient features of 9 cases of C. lusitaniae fungemia in neonates and susceptibility profiles of the isolates.
| Case | DOB | GA (wks/sex) |
Birth weight (g) | Date of bacterial septicaemia | Date of Candidemia | C. lusitaniae isolate no. | Catheters | Antibacterials used | Antifungals used | Outcome | Method | Minimum Inhibitory concentration (μg/ml) by Etest | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AP | FL | VO | CS | MYC | AND | ||||||||||||
| 1 | 7/5/11 | 24/M | 600 | 1/6/11MRSE D-25 | 17/5/11 D-10 | Kw 1812/11 | CVC,UAC UVC | AMP+AK,VAN, MEM | Ambisome | Expired 14/8/11 D-89 | E-test | 0.016 | 0.5 | 0.016 | 0.19 | 0.047 | 0.032 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | 0.5 | 0.12 | NA | |||||||||||
| 2 | 7/5/11 | 24/M | 625 | 20/5/11 S.epidermidis D-13 | 23/5/11 D-16 | Kw 1873/11 | CVC, UAC, UVC |
AMP+AK,TEC,TZP | Ambisome, FL | Expired 23/6/11 D-31 | E-test | 0.016 | 0.5 | 0.008 | 0.125 | 0.094 | 0.023 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.25 | 0.12 | NA | |||||||||||
| 3 | 20/10/13 | 28/F | 1200 | 14/11/13 Enterobacter D-25 | 17/11/13 D-28 | Kw 3863/13 | UVC | AMP+AK,TZP, VAN | Ambisome, FL, Cs | Discharged | E-test | 0.002 | 0.19 | 0.008 | 0.094 | 0.064 | 0.064 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.25 | 0.12 | NA | |||||||||||
| 4 | N.A | N.A | N.A | N.A | 11/5/14 | Kw 1606/14 | N.A | N.A | N.A | N.A | E-test | 0.023 | 0.5 | 0.004 | 0.094 | 0.125 | 0.047 |
| 5 | 12/8/14 | 32/M | 1500 | 27/8/14 P.aeruginosa D-15 24/9 E.faecalis+ P.aeruginosa D-43 |
4/9/14 D-23 | Kw 2727/14 | CVC, Urinary catheter | AMP+AK,MEM | AP, FL, CS | Expired 25/9/14 D-21 | E-test | 0.016 | 0.25 | 0.006 | 0.25 | 0.032 | 0.016 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.12 | 0.12 | NA | |||||||||||
| 6 | 11/3/15 | 25/F | 780 | 27/3/15 S.epidermidis D-16, 22/5 K.pneumoniae D-72 | 10/5/15 D-60 | Kw 1565/15 | CVC | AMP+AK MEM,VAN | Ambisome, FL | Discharged | E-test | 0.094 | 0.75 | 0.002 | 0.016 | 0.032 | 0.032 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.25 | 0.12 | NA | |||||||||||
| 7 | 3/7/15 | 36/F | 2280 | 10/8/15 K.pneumoniae D-38 | 14/8/15 D-42 | Kw 2473/15 | ─ | AMP+AK,MEM | AP, FL | Discharged | E-test | 0.064 | 0.75 | 0.023 | 0.19 | 0.125 | 0.032 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.25 | 0.12 | NA | |||||||||||
| 8 | 23/11/15 | 41/M | 2850 | 24/12/15 S.epidermidis D-31 | 25/12/15 D-32 | Kw 7/16 | CVC | AMP+AK TZP,MEM | Ambisome, FL | Discharged | E-test | 0.023 | 0.19 | 0.003 | 0.19 | 0.032 | 0.094 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.25 | 0.12 | NA | |||||||||||
| 9 | 28/5/16 | 27/F | 1030 | 26/6/16 K.pneumoniae D-29 | 9/7/16 D-42 | Kw 2212/16 | CVC | AMP+AK TZP,MEM | Ambisome, FL | Discharged | E-test | 0.032 | 0.5 | 0.003 | 0.012 | 0.047 | 0.023 |
| Vitek | ≤ 0.25 | ≤ 1 | ≤ 0.12 | ≤ 0.25 | ≤ 0.06 | NA | |||||||||||
Abbreviations:-DOB-date of birth, GA-gestation age, M-male, F-female, SVD-spontaneous vaginal delivery, MRSE-methicillin resistant Staphylococcus epidermidis, CVC-central venous catheter, UAC-umbilical arterial catheter, UVC-umbilical venous catheter, AMP-ampicillin, AK-amikacin, VAN-vancomycin, MEM-meropenem, TEC-teicoplanin, TZP-piperacillin tazobactam, AmBisome- ambisome, AP-amphotericin B, FL-fluconazole, CS-caspofungin, NA- Not available in Vitek. 2 AST-YS07; N. A., not available.