Table 4. Summary of cases of C. lusitaniae fungemia an deep-seated infections reported in literature in neonates and infants.
| Case Nos. |
Reference | Country | Age, Sex | Source of isolation | Underlying disease or condition | Chemotherapy/ steroids /neutropenia | Intravascular catheter | Prior antibiotics | Antifungal therapy | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christenson et al.; 1987 [44] | USA | 2 m, M | Bloo d, RT | Congenital heart disease | Yes | Yes | Yes | AP | Recovery |
| 2 | Sanchez & Cooper; 1987 [57] | USA | 7 d, M | Blood, Urine, CSF | Prematurity | No | Yes | Yes | AP | Recovery |
| 3 | Yinnon et al; 1992 [58] | USA | 14 d, M | Blood, Urine, Catheter | Prematurity, CVL | No | Yes | Yes | AP, 5FC, KE | Recovery |
| 4 | Oleinik et al; 1993 [45] | USA | 8 d, M | blood | Prematurity | - | - | - | AP, FL, 5FC | Recovery |
| 5 | Nguyen et al; 1996 [30] | USA | 4 m, M | Blood, Catheter | CVL, cardiac surgery | - | Yes | - | AP | Recovery |
| 6 | Fowler et al; 1998 [27] | USA | 21 d, NA | Urine | Prematurity | No | Catheter | Yes | AP, FL, 5FC | Recovery |
| 7 | Fowler et al; 1998 [27] | USA | 35 d, NA | blood, Urine, CSF | Prematurity | No | Catheter | Yes | AP, 5FC, FL | Death |
| 8 | Fowler et al; 1998 [27] | USA | 35 d, NA | blood | Prematurity | No | Yes | Yes | AP, FL, 5FC | Recovery |
| 9 | Levy et al; 2002 [59] | USA | 3 m, M | Blood, Urine | Chronic granulomatous disease | No | - | Yes | IT, AP, FL | Death |
| 10 | Viudes et al; 2002 [31] | Spain | 46 d, F | Blood, urine | Prematurity, Congenital nephrotic syndrome | Yes | - | Yes | L-AmB | Recovery |
| 11 | Favel et al; 2003 [49] | France | 12 d, M | Blood, Urine, Nephrostomy catheter | Prematurity | No | Yes | Yes | L-AmB, AP, FL | Death |
| 12 | Estrada et al; 2006 [60] | USA | 3 m, M | Lymph node | Chronic granulomatous disease | - | - | Yes | FL | Recovery |
| 13 | Taj-Aldeen et al; 2014 [40] | Qatar | 7 m, F | Blood | Malabsorption | - | - | - | L-AmB, FL | Recovery |
| 14 | Taj-Aldeen et al; 2014 [40] | Qatar | 20 d, M | Blood | Motor development delay | - | - | - | L-AmB | Recovery |
| 15 | Gautam et al; 2014 [61] | Nepal | 7 d twins, F & M | blood | Prematurity | Yes | Yes | Yes | FL | Recovery |
| 16 | Chorro-Mari et al; 2015 [43] | UK | 189 d | NA | Prematurity, Pyelonephritis | L-AmB, MYC | NA | |||
| 17 | Sariguzel et al; 2017 [62] | Turkey | 8 m, M | CSF | Meningitis,Ventricular drainage | Yes | - | Yes | FL | Death |
Abbreviations:- M-male, F- female, d- day, w-week, m-month, y- year, NA- not available, CVL- central venous line, ST-solid tumor, VPS- ventriculoperitoneal shunt, RT- respiratory tract, CSF- cerebrospinal fluid, NA- not available,DT-digestive tract AP- amphotericine B, FL- fluconazole, 5FC- 5 fluorocytosine, L-AmB- liposomal Amphotericin B, IT- itraconazole, VO- voriconazole, CS- caspofungin, MYC-micafungin