Table 2. Significant transcription factor binding sites associated with DRGs.

Index	Name	P-value	Adjusted p-value	Z-score	Combined score
1	SOX10 (human)	0.0001388	0.04219	-2.03	18.03
2	TEAD1 (human)	0.0005657	0.05334	-1.74	12.99
3	APEX1 (human)	0.0006451	0.05334	-1.77	12.98
4	RARA (human)	0.0007018	0.05334	-1.74	12.66
5	FOS (human)	0.004997	0.3038	-1.72	9.12
6	NR1H2 (human)	0.008450	0.4281	-1.87	8.91
7	CEBPE (human)	0.02180	0.5956	-1.89	7.24
8	JUN (human)	0.01382	0.5956	-1.56	6.67
9	LOC135440 (human)	0.02634	0.5956	-1.78	6.47
10	CBX5 (human)	0.03050	0.5956	-1.83	6.40

Binding motifs were detected at the gene promoter using Enrichr Tool through scanning the TRANSFAC and JASPAR databases. The TRANSFAC and JASPAR Position weight Matrices (PWM) table list the most highly significant 10 transcription factors. The combined score is calculated by taking the log of the p-value from the Fisher exact test and multiplying that by the Z-score of the deviation from the expected rank.