Figure 4.

Severely impaired podocyte foot process (FP) structure of Nphs2.Cre⁺;Coq6^flox/flox mutant mice can be preserved by 2,4-diHB administration. SEM representative images in 10.5-month-old mice. Nphs2.Cre⁺;Coq6^flox/flox mutant mice reveal severely impaired podocytic morphology with coarsened cell bodies (CBs) and major processes (MPs; arrow heads) as well as effaced FPs (asterisks). In contrast, Nphs2.Cre⁺;Coq6^flox/flox mutant mice under treatment with 2,4-diHB display normal three-dimensional podocyte morphology, slightly enlarged MPs, and FPs retaining their normal morphology. Scale bars, 4 μm left panel, 2 μm middle and right panels.