Fig 4. Coupled canonical circuit (CCC) model: Two Src neurons and two Int neurons lead to a common Tgt neuron.

A: Model schematic. For the simulations shown here, the Int neurons were electrically coupled and were reciprocally connected by an inhibitory synapse. Each Src neuron receives its own input, with timing difference between the two inputs Δt_inp. B: Examples of Tgt PSP for different electrical synapse strengths between interneurons of the coupled network (colored lines and legends). Each subpanel shows PSPs for different input timing differences Δt_inp (left: 2 ms, right: 4.4 ms), and strength of reciprocal inhibition G_GABA→Int (top: 1 nS, bottom: 7 nS). Scale bar is 1 mV, 1 ms. Colored symbols represent the spike times of Int₁ (circles ●) and Int₂ (triangle ▲), with colors representing different values of G_elec between the two interneurons. Symbols are vertically separated for clarity. C-D: Integration window and AUC of the PSP in Tgt for varied strengths of G_elec (0–5 nS) and G_GABA→Int (1, 3, 5, 7 nS from left to right).