Fig 6. Fractional glucose flow along the proximal tubule (PT), obtained for baseline conditions and with SGLT2 inhibition.

Under baseline conditions, the SGLT2 reabsorbed ∼90% of the filtered glucose, with the remaining glucose reabsorbed via the SGLT1 along the S3 segment. With SGLT2 blockade, 56% of the filtered glucose is reabsorbed, primarily via the SGLT1.