Table 3. Urine flow (per kidney) and composition, obtained under differing conditions.

*Model with human GFR and anatomical parameters, but rat transporter densities and permeabilities.

	Baseline	Measured	GFR & dimensions*	SGLT2 inhibition	NKCC2 inhibition
Flow (ml/min)	0.62	0.55–1.4 [33]	0.41	1.5	1.7
Na+ (mM)	73	51–191 [34]	83	44	47
K+ (mM)	72	19–67 [34]	52	52	62
Cl− (mM)	69	53–237 [34]	52	69	87
Urea (mM)	280	155–388 [34]	260	198	111
pH	6.2	6.2 [33]	5.1	6.4	6.3