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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Pharmacol Biochem Behav. 2018 Dec 28;177:27–33. doi: 10.1016/j.pbb.2018.12.009

Figure 2.

Figure 2.

ZCZ011 in combination with low-dose JZL184 attenuates gastric hemorrhage formation. Separate groups of male mice were administered JZL184 (40 mg/kg) 2 h prior to diclofenac (100 mg/kg, p.o.) or ZCZ011 (10 or 40 mg/kg) 75 min prior to diclofenac or a combination of JZL184 (1 m/kg, i.p.) and ZCZ011 (10 or 40 mg/kg, i.p.). (A) JZL184 (40mg/kg, i.p.), but not ZCZ011 (10 or 40 mg/kg, i.p.), attenuated ulcer formation when administered alone (n=8, except the JZL 40 group, which has n=7). (B) In combination with JZL184 (1 mg/kg, i.p.), ZCZ011 (10 or 40 mg/kg, i.p.) blocked ulcer formation (n=8, expect the JZL 1 and JZL + ZCZ011 10 groups, which have n=7 and n=9, respectively). Data represent mean ± SEM (n = 7–9/group). *p < .05 vs. vehicle; # p < .05 vs. diclofenac, † p < .05 vs. JZL184.