Table 2.

Varied Model Parameter Values

Parameter Description	Symbol	Base Case	Range	Source
Transmission parameter	β	.3	.05–.5	[16]
Vaccine efficacy (initial)	e	.95	.8–1	[15, 16, 23, 24]
Reduction in risk of infection for vaccinated (and protected) individuals	e p	1	.5–1	[25]
Duration of protection from vaccination	1/ω1	19.2 years	5–25 years	[16, 24]
Fraction symptomatic	σ	.2	.1–1	[16]
Fraction symptomatic for vaccinated individuals	σ V	.05	0–.2	[15, 23, 25]}
Fraction treated	τ	.75	0–1	[16, 26]
Duration of infectiousness with treatment	1/Υ	1 week	.5–3 weeks	[19]
Rate of treatment-induced/acquired resistance	ρ	.1 per week	.01–2 per week	Assumption
Natural recovery rate from first, antimicrobial-resistant infection	δ 1,R	.2 per week	.1–.5 per week	[19]
Relative infectiousness of resistant strain(s)	r R	.9	.5–2	Assumption, [27]
Relative infectiousness of chronic carriers	r C	.35	.1–1	[16]
Fraction that become carriers from first, antimicrobial-sensitive infection	θ 1,S	.03	.003–.1	[28]
Fraction that become carriers from first, antimicrobial-resistant infection	θ 1,R	.03	.003–.1	[28]
Relative rate of recovery from second infection	δ 2,S/δ1,S = δ2,R/δ1,R	1	.5–2	Assumption