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. Author manuscript; available in PMC: 2019 Mar 11.
Published in final edited form as: Leukemia. 2018 Sep 11;33(3):671–685. doi: 10.1038/s41375-018-0248-0

Figure 8. Combined AZD6244 and oligomycin treatment effectively inhibits the growth of human and mouse leukemia cells in vitro.

Figure 8

Leukemia cells from moribund Kras G12D/+ mice (carrying Mx1-Cre or Vav-Cre) with advanced JMML-like phenotypes (n=5) (A) or from human JMML patients (n=2) (B) were cultured in triplicate in 96-well plates in the presence of vehicle or various concentrations of AZD6244 and/or oligomycin for 5 days (A) or 14 days (B). Cell number was quantified using the CellTiter-Glo assay. Data are presented as mean ± s.d.