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. Author manuscript; available in PMC: 2019 Aug 27.
Published in final edited form as: Nature. 2019 Feb 27;567(7746):127–131. doi: 10.1038/s41586-019-0990-0

Figure 1 |. Crystal structure of KCTD16 BTB domain in complex with GABAB2 C-terminal peptide.

Figure 1 |

a, Schematic representation of the domain organization of GABAB2 receptor, KCTD12 and KCTD16. Summary of GST pull-down results with GST-tagged GABAB2 fragments and KCTD16 BTB domain. b, Ribbon representation of the KCTD16BTB/GABAB2 peptide complex structure. c, Detailed view of the interface indicated on the structure by the black box in panel (b). d, Subcellular localization of GFP-KCTD12 or GFP-KCTD12-F87A (equivalent to F80A in KCTD16) with or without GABAB receptor in HEK293T cells.