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. Author manuscript; available in PMC: 2019 Aug 27.
Published in final edited form as: Nature. 2019 Feb 27;567(7746):127–131. doi: 10.1038/s41586-019-0990-0

Figure 4 |. Proposed mechanism for GIRK channel desensitization.

Figure 4 |

GABAB2 receptor is tethered via a long linker to KCTD12, which may allow it to diffuse far from the membrane. Gβγ subunits are released from Gαi/o by activated receptor, but are membrane-tethered and rapidly associate with GIRK channels. Association of KCTD12 with a single GIRK-bound Gβγ subunit tethers KCTD12 to the membrane, allowing it to rapidly strip remaining Gβγ subunits from the activated channel. Note that distances cannot be shown to scale due to the extreme length of the tether between the GABAB2 transmembrane domain and the KCTD12 binding site.