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. Author manuscript; available in PMC: 2019 Apr 17.
Published in final edited form as: Chem Rev. 2018 Sep 7;119(2):1323–1455. doi: 10.1021/acs.chemrev.8b00201

Figure 78.

Figure 78

Structures of hMetAP2 with: LAF153 (PDB 1QZY), A311263 (PDB 1R5G), MetAPi-2 (PDB 2ADU), MetAPi-4 (PDB 2OAZ), MetAPi-8 (PDB 5JI6), and MetAPi-10 (PDB 5LYX). Crystal structures of EcMetAP with: MetAPi-16 (PDB 1XNZ), MetAPi-18 (PDB 4A6W), MetAPi-20 (PDB 3D27). Co2+ ions shown as blue spheres and Mn2+ ions shown as magenta spheres.