Table 17.
Activity of Glol inhibitors. All values shown are against human Glol, unless otherwise noted.
| Compound | Inhibition (μM) | Ref. |
|---|---|---|
| Glo1i-1 | IC50 = 20a | 1150 |
| Glo1i-2 | IC50 = 9a | 1151 |
| Glo1i-3 | Ki = ~400a | 1157 |
| Glo1i-4 | IC50 = 120 | 1158 |
| Glo1i-5 | IC50 = 280 | 1158 |
| Glo1i-6 | IC50 = 530 | 1158 |
| Glo1i-7 | IC50 = 210 | 1158 |
| Glo1i-8 | IC50 = 3.5 | 1159 |
| Glo1i-9 | IC50 = 34a | 1160 |
| Glo1i-10 | IC50= 154a | 1160 |
| Glo1i-11 | Ki = l.7 | 1161 |
| Glo1i-12 | Ki = 0.01 | 1146 |
| Glo1i-13 | Ki = 0.001 | 1162 |
| Glo1i-14 | IC50 = 1.19 | 1163 |
| Glo1i-15 | IC50 = 0.011 | 1163 |
| Baicalein | Ki = 0.183 | 1164 |
| Indomethacin | Ki = 18.1b | 1165 |
| Methyl-gerfelin | Ki = 0.23b | 1166 |
| Myricetin | IC50 = 5.0 | 1167 |
| Zopolrestat | Ki = 1.2 | 1168 |
a
Value reported against yeast Glo1.
b
Value reported against mouse Glo1.