Table 6.
Activity (IC50 values) of RNase-H inhibitors.
| Compound | Inhibition (μM) | Ref. |
|---|---|---|
| RNaseHi-1 | 15 | 426 |
| RNaseHi-2 | 1 | 403 |
| RNaseHi-3 | 50 | 403 |
| RNaseHi-4 | 3.5 | 432 |
| RNaseHi-5 | 1.2 | 437 |
| RNaseHi-6 | 2.7 | 438 |
| RNaseHi-7 | 0.65 | 441 |
| RNaseHi-8 | 0.43 | 439,440 |
| RNaseHi-9 | >50 | 439,440 |
| RNaseHi-10 | >50 | 439,440 |
| RNaseHi-11 | >50 | 439,440 |
| RNaseHi-12 | >50 | 439 |
| RNaseHi-13 | 0.061 | 421 |
| RNaseHi-14 | 0.15 | 444 |
| RNaseHi-15 | 0.11 | 444 |
| RNaseHi-16 | 0.045 | 444 |
| RNaseHi-17 | 10 | 445 |
| RNaseHi-18 | 11 | 445 |
| RNaseHi-19 | 0.05 | 446 |
| RNaseHi-20 | >10 | 446 |
| RNaseHi-21 | 0.2 | 446 |
| AZT-MP | 50 | 431 |
| BTDBA | 3.2 | 436 |
| GSK5750 | 0.33 | 445 |
| Manicol | 1.5 | 427 |
| RDS 1643 | 13 | 447 |
| β-Thujaplicinol | 0.2 | 427 |