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The plasmin–PA–MMP cascade. The PAs, PLAT or PLAU, are able to cleave plasminogen to plasmin. Plasmin has numerous actions, including activation of the MMP system to bring about matrix breakdown. Plasminogen activator action is regulated by PA inhibitors (SERPINE1 and SERPINB2) wheras MMP activity is regulated in the extracellular environment by the MMP inhibitors, the TIMPs.
