Table 5.
Chemokines Produced in Response to LH Surge in the Ovaries of Humans or Nonhuman Primates
| Chemokine | Functions in Ovulation | References |
|---|---|---|
| CCL2 | Secreted by granulosa cells, macrophages, and stromal fibroblasts; attracts T cells, monocytes, basophils, dendritic cells, and natural killer cells | (372–374) |
| CCL20 | Secreted by granulosa cells and theca cells; attracts monocytes, macrophages, dendritic cells, B cells, and T cells | (126, 372) |
| CCL25 | Secreted by theca cells; attracts monocytes, B cells, T cells, and natural killers cells | (375) |
| CSF1 | Secreted by granulosa cells; induces differentiation of monocytes into macrophages | (372, 376) |
| CSF2 | Secreted by granulosa and theca cells; attracts monocytes and macrophages | (376) |
| CXCL1 | Secreted by granulosa cells, monocytes, macrophages, and dendritic cells; attracts neutrophils | (377) |
| CXCL8 | Secreted by granulosa cells, macrophages, and epithelial, endothelial, and mast cells; attracts neutrophils, basophils, and T cells | (378) |
| CXCL10 | Secreted by granulosa cells; attracts T cells, natural killer cells, B cells, dendritic cells, monocytes, and macrophages | (379, 380) |
| CXCL12 | Secreted by granulosa cells, endothelial cells, and stromal fibroblasts; attracts monocytes, macrophages, B cells, T cells, neutrophils, and dendritic cells | (380, 381) |
| CXCL16 | Secreted by granulosa cells; attracts monocytes, B cells, T cells, and natural killer cells | (382) |