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. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018

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Copyright © 2019 Mathieu and Boulanger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNA methylation and H3K27 trimethylation in intronic enhancer results in decreased PLPP3 expression and leads to increased LysoPA level, which promotes osteogenic signaling (With permission from Mkannez et al. (55). EED, embryonic ectoderm development; SUZ12, SUZ12, polycomb repressive complex 2 subunit; EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; DNMT3, DNA methyltransferase 3 like.